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科研喵使用ai读文献,祝你效率百倍,访问labcat.com.cn下载。本期关注发表在Environmental Science & Technology (IF: 10.8)上的重要研究"Prenatal Insecticide Exposure and Adverse Birth Outcomes: Evidence for Mediation via Disruptions in Amino Acid and Acylcarnitine Metabolism"。这项研究发现,孕期接触杀虫剂会影响新生儿健康,特别是通过扰乱氨基酸和酰基肉碱代谢途径。研究显示,第三孕期暴露于特定杀虫剂(3-PBA和DEDTP)与新生儿出生体重显著降低相关,而另一种杀虫剂DMTP则与更长的孕周相关。更重要的是,研究者发现C18:2酰基肉碱介导了杀虫剂暴露与低出生体重之间的关联,这为理解环境毒素如何影响胎儿发育提供了新视角,也为预防不良出生结局提供了潜在靶点。