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科研喵使用ai读文献,祝你效率百倍,访问labcat.com.cn下载。本期关注发表在《Environmental science & technology》(IF: 10.8)上的重要研究"Prenatal Insecticide Exposure and Adverse Birth Outcomes: Evidence for Mediation via Disruptions in Amino Acid and Acylcarnitine Metabolism"。这项针对406对母婴的前瞻性队列研究发现,孕期接触杀虫剂会影响新生儿健康。第三孕期尿液中3-PBA和DEDTP水平与出生体重显著降低相关,而DMTP则与更长的孕周相关。研究首次揭示了杀虫剂暴露通过扰乱新生儿氨基酸和酰基肉碱代谢通路,特别是亚油酰肉碱介导的能量代谢紊乱,导致不良出生结局的机制。这一发现为孕期环境健康干预提供了重要科学依据。