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科研喵使用ai读文献,祝你效率百倍,访问labcat.com.cn下载。今天我们要介绍发表在Journal of cellular physiology (IF: 4.5)上的重要研究"TTC7B Activates the AKT-JKAMP Signaling Axis to Promote Tumor Progression in Head and Neck Cancer"。这项研究揭示了TTC7B蛋白在头颈癌中的关键作用——它通过激活AKT-JKAMP信号轴促进肿瘤进展,同时创造免疫抑制性微环境。研究发现,高表达TTC7B与患者不良预后显著相关,而抑制这一信号通路可有效遏制癌细胞迁移和侵袭。这一发现不仅为头颈癌提供了新的预后生物标志物,更为开发靶向治疗策略开辟了新途径,有望改善头颈癌患者的临床治疗效果。