In the second episode of our podcast 'about enzymes & molecules', we welcome Dr Roland Stocker to talk about bilirubin, the antioxidant molecule produced during heme breakdown by heme oxygenase. Dr Stocker will tell us about the inspiration that led to hypothesize that bilirubin possesses antioxidant properties, the thorough methodological approaches that were required to precisely demonstrate this effect, and how bilirubin can protect cellular membranes, albumin, lipoproteins and other cellular structures from the damage caused by free radicals. We will also discuss the epidemiological studies that support an important role for bilirubin in mitigating cardiovascular disease and diabetes complications, ending with potential therapeutic approaches based on bilirubin derivatives that are currently investigated in some laboratories. We hope you'll appreciate Dr Stocker's expertise and excellent explanations on this subject. #aboutenzymesandmolecules