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In this podcast, Professor Robert Storey and Dr Marc Bonaca discuss options for treating and managing a male patient aged 68 years with inferior ST-segment elevation myocardial infarction (STEMI) who is at high risk of bleeding and ischaemia. In this episode, they discuss evidence from clinical trials including ISAR-REACT5, PLATO and TRITON, and how that evidence informs their treatment considerations for this patient.