Arkana Advances is a research podcast, hosted by Dr. Rebecca May, discussing the work of Arkana physicians and scientists as they ask questions that lead to advancing the understanding of disease.
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Arkana Advances is a research podcast, hosted by Dr. Rebecca May, discussing the work of Arkana physicians and scientists as they ask questions that lead to advancing the understanding of disease.
Viral-like Inclusions in COVID-19 Negative Renal Biopsies by Electron Microscopy
Arkana Advances
14 minutes 18 seconds
4 years ago
Viral-like Inclusions in COVID-19 Negative Renal Biopsies by Electron Microscopy
In Episode 4 of Arkana Advances, Dr. May interviews Dr. Cassol over her recent publication discussing viral-like inclusions in COVID-19 negative renal biopsies detected by electron microscopy.
Early in the COVID-19 pandemic in the United States, few publications from different organ systems claimed to have found COVID-19 viral particles, including in the kidney. Viral particles are known to be of varying sizes, making proper identification even more difficult. To see whether these viral particles are specific for COVID-19 infection, both pre-COVID and COVID-era biopsies were examined. Viral-like inclusions were seen in all cases studied. These mimickers of COVID virions are hypothesized to be clathrin-coated endocytic vesicles, microvesicular bodies, or small organelles. COVID-19 ISH was performed in a few cases of patients with active COVID, and no viral RNA was detected. The CDC has outlined principles of identification of viruses on electron microscopy, including the proper protocols for preparation of the samples.
Read the Paper: Viral-like Inclusions in COVID-19 Negative Renal Biopsies by Electron Microscopy
[embed]https://youtu.be/45-ZHL1gVSc[/embed]
Arkana Advances
Arkana Advances is a research podcast, hosted by Dr. Rebecca May, discussing the work of Arkana physicians and scientists as they ask questions that lead to advancing the understanding of disease.
