Collaborative practice agreements (CPAs) are formal agreements between pharmacists and other healthcare providers that allow pharmacists to perform specific tasks independently at the top of their license. CPAs are a powerful tool widely used in the outpatient setting but not used as frequently in the inpatient setting. This episode discusses the considerations for developing and implementing a successful inpatient CPA and the benefits to patient care quality, safety, and efficiency. The information presented during the podcast reflects solely the opinions of the presenter. The information and materials are not, and are not intended as, a comprehensive source of drug information on this topic. The contents of the podcast have not been reviewed by ASHP, and should neither be interpreted as the official policies of ASHP, nor an endorsement of any product(s), nor should they be considered as a substitute for the professional judgment of the pharmacist or physician.