The Centers for Disease Control and Prevention recently released its Core Elements of Hospital Diagnostic Excellence. Given the significant implications of diagnostic stewardship on the use of antimicrobials, US Antibiotic Awareness Week is an excellent opportunity to begin to unpack this topic. This podcast reviews the core elements and explores the opportunities for pharmacists to engage in diagnostic stewardship and how this topic has broader implications beyond antimicrobial use.  The information presented during the podcast reflects solely the opinions of the presenter. The information and materials are not, and are not intended as, a comprehensive source of drug information on this topic. The contents of the podcast have not been reviewed by ASHP, and should neither be interpreted as the official policies of ASHP, nor an endorsement of any product(s), nor should they be considered as a substitute for the professional judgment of the pharmacist or physician.