Most people accept aging as inevitable. Aubrey de Grey refuses to.

In this episode, the world’s most recognized longevity scientist breaks down why aging is a solvable engineering problem — not a mystery of biology.

Aubrey shares the moments that shaped his mission to defeat death, the science behind “longevity escape velocity,” and how AI breakthroughs like AlphaFold are accelerating humanity’s fight against aging.

He also reveals what he actually does to stay biologically younger at 62 — from cutting-edge diagnostics to his take on rapamycin, plasma exchange, GLP-1s, and Brian Johnson’s Blueprint.

If you’re a founder, technologist, or anyone fascinated by the future of the human body — this conversation will completely reframe how you think about aging, biology, and time itself.

Most people accept aging as inevitable. Aubrey de Grey refuses to.In this episode, the world’s most recognized longevity scientist breaks down why aging is a solvable engineering problem - not a mystery of biology.Aubrey shares the moments that shaped his mission to defeat death, the science behind “longevity escape velocity”, and how AI breakthroughs like AlphaFold are accelerating humanity’s fight against aging.He also reveals what he actually does to stay biologically younger at 62 — from cutting-edge diagnostics to his take on rapamycin, plasma exchange, GLP-1s, and Brian Johnson’s Blueprint.If you’re a founder, technologist, or anyone fascinated by the future of the human body — this conversation will completely reframe how you think about aging, biology, and time itself.Follow AGI:Instagram: https://www.instagram.com/besuperhumanpod/Threads: https://www.threads.com/@besuperhumanpodX: https://x.com/BeSuperhumanPodFacebook: https://www.facebook.com/podsuperhumanTikTok: https://www.tiktok.com/@podsuperhuman

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Listen to all episodes: https://www.besuperhumanpod.com/

Learn more about Aubrey de Grey:https://www.sens.org/

Chapters

00:00 – Intro01:00 – The childhood moment that defined Aubrey’s mission
03:00 – Why he chose science over entrepreneurship
06:00 – The dinner conversation that changed everything
08:00 – Why scientists ignored aging for decades
10:00 – The “Pro-Aging Trance”: why society fears immortality
13:00 – The illusion that death gives life meaning
15:00 – Why aging causes more suffering than anything else
17:00 – What “Longevity Escape Velocity” actually means
20:00 – How damage repair could stop aging altogether
24:00 – Can humans reach escape velocity by the 2030s?
27:00 – How AI, AlphaFold, and CRISPR accelerate longevity research
31:00 – Why AI still can’t replace lab work
34:00 – Aubrey’s personal longevity regimen at 62
37:00 – His take on biological age tests and measurement
40:00 – Hot or Not: Rapamycin, Metformin, Plasma Exchange, GLP-1s
45:00 – Sauna, cold plunge, and diet myths
49:00 – Why meal replacements might miss key nutrients
52:00 – How AI could uncover unknown molecules in our blood
56:00 – The most promising anti-aging therapies today
1:00:00 – Stem cell rejuvenation and the monkey experiment
1:04:00 – How stem cells can resist aging environments
1:08:00 – Why multiple breakthroughs—not one—will defeat aging
1:12:00 – The future of longevity research
1:18:00 – Final thoughts: living long enough to live forever