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Biomanufacturing & Fermentation Technology
prasad ernala
11 episodes
3 days ago
Welcome to Biomanufacturing & Fermentation Technology, the podcast where microbes meet manufacturing and science turns into scalable reality. In each episode, we dive inside real bioprocesses. from lab-scale experiments to commercial fermenters. to unpack how products are actually made, fixed, and optimized in the real world. Expect candid conversations on fermentation failures and breakthroughs, scale-up war stories, regulatory realities, emerging technologies, and the decisions that separate a promising culture from a profitable process. Whether you are a scientist, engineer, entrepreneur, o
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Science
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All content for Biomanufacturing & Fermentation Technology is the property of prasad ernala and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
Welcome to Biomanufacturing & Fermentation Technology, the podcast where microbes meet manufacturing and science turns into scalable reality. In each episode, we dive inside real bioprocesses. from lab-scale experiments to commercial fermenters. to unpack how products are actually made, fixed, and optimized in the real world. Expect candid conversations on fermentation failures and breakthroughs, scale-up war stories, regulatory realities, emerging technologies, and the decisions that separate a promising culture from a profitable process. Whether you are a scientist, engineer, entrepreneur, o
Show more...
Science
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Managing Acetate Accumulation in Recombinant E. coli Fed-Batch Processes
Biomanufacturing & Fermentation Technology
30 minutes 53 seconds
3 weeks ago
Managing Acetate Accumulation in Recombinant E. coli Fed-Batch Processes

This is particularly with recombinant Escherichia coli strains. It

draws from a real-world case study of unexpected acetate, lactate, glycerol, or organic acid

accumulation during fed-batch operations, caused by feed strategy misalignment with cellular uptake

kinetics. The focus is on a recombinant E. coli vaccine antigen process that failed GMP batches due to

acetate toxicity at pilot scale

Biomanufacturing & Fermentation Technology
Welcome to Biomanufacturing & Fermentation Technology, the podcast where microbes meet manufacturing and science turns into scalable reality. In each episode, we dive inside real bioprocesses. from lab-scale experiments to commercial fermenters. to unpack how products are actually made, fixed, and optimized in the real world. Expect candid conversations on fermentation failures and breakthroughs, scale-up war stories, regulatory realities, emerging technologies, and the decisions that separate a promising culture from a profitable process. Whether you are a scientist, engineer, entrepreneur, o