Nanobodies, the smallest functional fragments of antibodies derived from camelids such as llamas and camels, are transforming our approach to diagnostics, therapeutics, and research. These single-domain antibodies, composed solely of the variable domain of heavy-chain antibodies (VHH), offer significant advantages over traditional antibodies, including greater stability, solubility, and the ability to access cryptic epitopes. This article explores the unique structure, production methods, and groundbreaking applications of nanobodies in science and medicine. Stay curious, stay innovative. I'm Luke McLaughlin. If you would like to learn more about this topic consider reading our full length articles on biotechnologyreviews.com Or consider our podcast series on youtube or Spotify at our Biotechnology Reviews Channel. Our articles are also available on our linkedin newsletter Biotechnology Reviews.