Trispecific antibodies represent an innovative class of biotherapeutic agents designed to engage multiple therapeutic targets simultaneously. By combining the binding specificities of three different antibodies into a single molecule, trispecific antibodies can orchestrate complex biological responses, offering a multifaceted approach to treating diseases, particularly cancer and autoimmune disorders. This overview will delve into the design, mechanism of action, applications, advantages, challenges, and future prospects of trispecific antibodies. Stay curious, stay innovative. I'm Luke McLaughlin. If you would like to learn more about this topic consider reading our full length articles on www.biotechnologyreviews.com Or consider our podcast series on youtube or Spotify at our Biotechnology Reviews Channel. Our articles are also available on our linkedin newsletter Biotechnology Reviews.