Neurodegenerative diseases are disorders characterised by a gradual, yet steady, loss or death of neurons, the brain cells, a condition that eventually leads to decline in motor and cognitive functions. Despite our best efforts, some aspects of these diseases are still obscure. Rina Demjaha is a medical doctor and a PhD candidate at the Medical University in Graz, Austria. With her we will explore some of the experimental techniques which are used to identify so-called biomarkers which could lead to an early diagnosis of such diseases.