Seed-grown cannabis has been talked about for years, but most commercial growers still lean on clones for consistency. In this episode, Dr. Matthew Indest and I dig into whether the industry is finally approaching a true shift. We unpack the science, the barriers, and the practical realities: genetic stability, uniformity, agronomic traits, pathogen concerns, breeding strategies, and the economics behind large-scale seed adoption. Dr. Indest brings a rare mix of rigorous plant science and real-world cannabis experience. If you’ve wondered whether seed-based cultivation can match or even outperform clonal systems — or what breeders actually need to deliver for that future to happen — this episode lays it out clearly.