Step into the future of medicine and manufacturing, where a remarkable class of compounds called cyclodextrins (CDs) is transforming the landscape of 3D and 4D printing for critical biomedical and pharmaceutical applications.Imagine 3D printed objects that dynamically change shape in response to environmental cues like moisture or temperature – a concept known as 4D printing, vividly demonstrated by a shape-shifting flower with variable flexibility.These safe, sustainable, and highly versatile cyclodextrins enable homogeneous dispersion of challenging drugs in water-based mixtures, foster self-healing properties, and provide tunable architectures sensitive to a range of stimuli.Crucially, cyclodextrins are powering the shift towards personalized medicine, especially for pediatric patients, allowing for the Direct Powder Extrusion (DPE) 3D printing of customized dosage forms, like Mini-Tablets, that precisely deliver drugs such as budesonide with enhanced solubility and site-specific release to target conditions like eosinophilic colitis.Beyond printing, their applications extend to polymeric nanoparticles, one-dimensional nanostructures (nanofibers), and hydrogels for advanced drug delivery, tissue engineering, and wound healing, underscoring their profound impact on healthcare innovation.