Caring for individuals with thymidine kinase 2 (TK2) deficiency can place extraordinary demands on families, yet caregiver experiences are often overlooked in clinical care. To shed light on this burden, a mixed-methods study explored the physical, emotional, and financial impacts on caregivers. Here with Dr. Charles Turck to share the findings and how we can better support these families is Dr. Philip Yeske, the United Mitochondrial Disease Foundation Science and Alliance Officer.