This month on Curiosity Killed the Rat, Kade and Matt tackle a more serious issue: the science of antidepressants. What is depression? How is it caused? How do antidepressants work, and are they actually effective? Stick around to the end of the episode to hear sound guy Matt answer a listener question about the science of noise cancelling headphones! As always, you can find us @curiosityrat on twitter, instagram, and facebook, and send your listener questions in to curiosityrat@gmail.com. We also have a Patreon! If you love our content and want to support us you can jump on to https://www.patreon.com/curiosityrat and become a patron. There is absolutely ZERO pressure but if you have as little as $1/month you can chuck it our way to help us out and show you appreciate all the time and effort that goes into making this show. References: https://www.nature.com/articles/s41380-022-01661-0 https://www.kcl.ac.uk/news/a-response-to-the-serotonin-theory-of-depression-a-systematic-umbrella-review-of-the-evidence https://www.sciencemediacentre.org/expert-reaction-to-a-review-paper-on-the-serotonin-theory-of-depression/ https://www.psychiatry.org/patients-families/depression/what-is-depression science.org/content/blog-post/understanding-antidepressants---or-not https://www.ncbi.nlm.nih.gov/books/NBK361016/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309382/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739676/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896866/ https://www.nature.com/articles/mp201080 https://helda.helsinki.fi/items/5f15e844-28d8-41b9-a61c-38b2b3351a95 Listener Question References: https://www.nytimes.com/wirecutter/blog/what-noise-cancelling-headphones-do/ https://www.scienceabc.com/innovation/why-are-noise-canceling-headphones-less-effective-at-blocking-high-pitched-sounds.html https://www.soundguys.com/noise-canceling-anc-explained-28344/ https://hearingclinic.co.za/why-can-you-hear-when-your-ears-are-blocked/ https://www.ncbi.nlm.nih.gov/books/NBK531483/