In this episode, we explore findings from the CLODIfrail trial, a Danish study published in The Lancet Healthy Longevity (2024). The trial tested whether early, comprehensive geriatric assessment (CGA) could improve outcomes for older adults hospitalised with Clostridioides difficile infection. While 90-day mortality rates were similar between groups, those receiving CGA had fewer infection recurrences, shorter hospital stays, and fewer deaths directly linked to C. difficile. Researchers suggest that earlier access to faecal microbiota transplantation may be key to these improved results.
Research paper:
Rubak T, Baunwall SMD, Gregersen M, Paaske SE, Asferg M,Barat I, Secher-Johnsen J, Riis MG, Rosenbæk JB, Hansen TK, Ørum M, Steves CJ, Veilbæk H, Hvas CL, Damsgaard EMS. Early geriatric assessment and management in older patients with Clostridioides difficile infection in Denmark (CLODIfrail):a randomised trial. Lancet Healthy Longev. 2024 Dec;5(12):100648
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