In this episode, we dive into urticaria and erythema with a focus on intense itch, what’s actually driving the sensation and how to calm it down. We break down the role of histamine, when to consider H2 receptor blockers alongside H1s, and where some of the newer FDA-approved treatment options fit into your algorithm for stubborn cases. We also talk through practical pearls for counseling itchy patients so they feel validated, heard, and supported while you work toward long-term control.