In this episode, Rich and Pip discuss vaccine-induced immune thrombotic thrombocytopenia and heparin-induced thrombocytopenia. They critique a recent paper that has shown that VITT has been around before vaccines against Covid-19. Importantly, they discuss which patients should be tested for spontaneous VITT- and HIT-like syndromes, and discuss a recent case.
The paper is: Schönborn L. et al. Anti-PF4 immunothrombosis without proximate heparin or adenovirus vector vaccine exposure. Blood. 2023 Dec 28;142(26):2305-2314.
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In this episode, Rich and Pip discuss vaccine-induced immune thrombotic thrombocytopenia and heparin-induced thrombocytopenia. They critique a recent paper that has shown that VITT has been around before vaccines against Covid-19. Importantly, they discuss which patients should be tested for spontaneous VITT- and HIT-like syndromes, and discuss a recent case.
The paper is: Schönborn L. et al. Anti-PF4 immunothrombosis without proximate heparin or adenovirus vector vaccine exposure. Blood. 2023 Dec 28;142(26):2305-2314.
#6 The Noisy World of Transcriptional Dynamics with Justin Wheat
Don't Just Read the Guidelines
1 hour 1 minute 8 seconds
4 years ago
#6 The Noisy World of Transcriptional Dynamics with Justin Wheat
Justin Wheat is an MD/PhD student at the Albert Einstein Medical Centre in New York, USA. His expertise is in DNA transcription factors, how these influence haematopoiesis, and how they go wrong in leukaemia. We talk about the genesis of leukaemia and how transcription is at the heart of it, touching on well known transcription factors such as RUNX1, GATA1 and GATA2. Justin is a really good orator, and can explain difficult concepts really well.
You can check out his paper: Single-molecule imaging of transcription dynamics in somatic stem cells here: https://www.nature.com/articles/s41586-020-2432-4?proof=t and his recent review here: https://ashpublications.org/blood/article-abstract/138/8/625/476230/Gene-expression-at-a-single-molecule-level?redirectedFrom=fulltext
Find Justin on Twitter @JCWheat4
Don't Just Read the Guidelines
In this episode, Rich and Pip discuss vaccine-induced immune thrombotic thrombocytopenia and heparin-induced thrombocytopenia. They critique a recent paper that has shown that VITT has been around before vaccines against Covid-19. Importantly, they discuss which patients should be tested for spontaneous VITT- and HIT-like syndromes, and discuss a recent case.
The paper is: Schönborn L. et al. Anti-PF4 immunothrombosis without proximate heparin or adenovirus vector vaccine exposure. Blood. 2023 Dec 28;142(26):2305-2314.
