The Environmental and Energy Study Institute (EESI) and the Ohio River Basin Alliance held a briefing outlining how policymakers and community stakeholders can help restore the health of the Ohio River. The Ohio River is an important driver of economic growth for the six states it runs through—Pennsylvania, Ohio, West Virginia, Kentucky, Indiana, and Illinois. It also supplies drinking water for more than 30 million people. However, impacted by toxic waste and sewage, mining and agricultural runoff, and inadequate water infrastructure, the Ohio River is considered one of the most heavily polluted rivers in the country. It also faces conservation challenges, from habitat loss to the spread of invasive species. This briefing unpacked the challenges and opportunities embedded in increasing the health and resilience of the Ohio River Basin. In particular, panelists addressed the disproportionate impact of both pollution and flooding on economically disadvantaged communities. Policymakers left with an understanding of how collaboration between community stakeholders, industry, and federal, state, and local governments advances pollution remediation work, conservation efforts, and climate resilience projects.