In this episode of Everything Explained, we explore why uncertainty feels so deeply uncomfortable—and why your brain reacts to it as if something is wrong. From our evolutionary past to the brain’s role as a prediction engine, we unpack how ambiguity triggers stress, heightens vigilance, and pushes us to seek certainty at almost any cost. We look at the chemistry of uncertainty, including the role of the amygdala, cortisol, and adrenaline, and explain why waiting, not knowing, and unclear outcomes can feel physically exhausting. The episode also reframes uncertainty as more than a threat, showing how it fuels learning, creativity, and growth when managed well. A thoughtful, practical guide to understanding uncertainty—not as a weakness, but as a signal you can learn to work with.