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From First Principles
Krishna Choudhary and Lester Nare
20 episodes
5 days ago
From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.
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All content for From First Principles is the property of Krishna Choudhary and Lester Nare and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.
Show more...
Science
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FFP EP. 16 | Octopus Camouflage, Orcas vs. Sharks, Civet Coffee & Sub-Diffraction Telescope Tech
From First Principles
1 hour 17 minutes 35 seconds
2 months ago
FFP EP. 16 | Octopus Camouflage, Orcas vs. Sharks, Civet Coffee & Sub-Diffraction Telescope Tech

Hosted by Lester Nare and Krishna Choudhary, this super-episode spans four wildly different frontiers: bioengineers hijacking bacterial evolution to mass-produce octopus camouflage pigment; orcas developing cultural hunting strategies against great white sharks; the bizarre chemistry behind civet-processed luxury coffee; and a UCLA breakthrough that pushes telescope resolution beyond the classical diffraction limit.


Summary

  • UCSD’s biosynthesis breakthrough — how researchers engineered a growth-coupled, plug-and-play metabolic pathway to mass-produce xanthomatin, the cephalopod pigment behind octopus camouflage.
  • Orca vs. shark culture wars — first-ever documentation of coordinated predation on juvenile great whites in Mexican waters, plus how whales transmit learned behavior socially.
  • The paradox of civet coffee — wild civet gut chemistry, medium-chain esters, and how microbial fermentation creates the world’s most expensive “biologically processed” coffee.
  • UCLA’s telescope hack — a mode-sorting instrument that extracts phase information from starlight, enabling sub-diffraction-limited imaging and revealing asymmetric hydrogen disks around distant stars.

Show Notes

  • UCSD — Nature Biotechnology (xanthomatin biosynthesis)
  • Orca Predation Study — Frontiers in Marine Science
  • Civet Coffee Chemistry — Nature Scientific Reports
  • UCLA Sub-Diffraction Telescope Method — ApJ Letters
From First Principles
From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.