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From First Principles
Krishna Choudhary and Lester Nare
20 episodes
2 days ago
From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.
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All content for From First Principles is the property of Krishna Choudhary and Lester Nare and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.
Show more...
Science
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FFP EP. 4 | 3rd Interstellar Visitor, Rubin’s Sky Camera, AI CRISPR Boost & T. rex Blood Vessels
From First Principles
1 hour 22 minutes 8 seconds
4 months ago
FFP EP. 4 | 3rd Interstellar Visitor, Rubin’s Sky Camera, AI CRISPR Boost & T. rex Blood Vessels

Interstellar visitor #3 is here. We unpack 3I ATLAS (why it’s moving so fast, why we finally saw a tail, and how Hubble/JWST—and maybe even Juno—could nail down its makeup). Then we dive into the Vera Rubin Observatory, the 32-gigapixel camera that will turn the entire sky into a time-lapse movie and supercharge discovery. Next: AI just boosted CRISPR by predicting and guiding DNA repair (Pythia), making edits cleaner—especially in non-dividing neurons. And we close with a crossover of dinos + particle physics: preserved T. rex blood vessels revealed by a synchrotron. Mystery Box: the viral “Black aliens” meme.


From First Principles
From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.