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From First Principles
Lester Nare and Krishna Choudhary
16 episodes
5 days ago
We break down the week’s biggest science headlines from first principles—because understanding the world shouldn’t require a PhD.
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Science
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All content for From First Principles is the property of Lester Nare and Krishna Choudhary and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
We break down the week’s biggest science headlines from first principles—because understanding the world shouldn’t require a PhD.
Show more...
Science
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FFP EP. 12 | From Princeton to the Nobel Prizes — How FFP Started + 2025 Nobel Recap
From First Principles
1 hour 12 minutes 17 seconds
1 month ago
FFP EP. 12 | From Princeton to the Nobel Prizes — How FFP Started + 2025 Nobel Recap

After a packed week of Nobel Prize coverage, Lester and Krishna look back on how From First Principles began and why they built it as an “ESPN for Science.” They revisit 2025’s Medicine, Physics and Chemistry winners and discuss why fundamental research and immigration policy are core to America’s scientific edge.


Quick note: this week’s episode is in vertical format because of a technical hiccup during recording — back to widescreen next week!


Summary

  • Origin Story — Two Princeton friends from different continents unite around a shared love of science and storytelling.
  • The Mission — Creating an “ESPN for Science” that celebrates research and the people behind it.
  • Nobel Follow-ups — Medicine (Tregs and non-immune roles), Physics (macroscopic quantum tunneling and quantum supremacy), Chemistry (MOFs and industrial scaling).
  • Funding + Immigration — Why public research grants and curating global talent are vital to scientific leadership.

Show Notes

  • Nobel Prize Press Release (2025 Medicine)
  • Nobel Prize Press Release (2025 Physics)
  • Nobel Prize Press Release (2025 Chemistry)
  • Nature Genetics (2001) — FOXP3 Mutation Causes Dysregulation
  • Nature (1999) — MOF-5 Discovery (Omar Yaghi et al.)
  • Google Quantum AI Lab — Quantum Supremacy (Nature, 2019)
From First Principles
We break down the week’s biggest science headlines from first principles—because understanding the world shouldn’t require a PhD.