Today, an in-depth look at puberty blockers and their use on minors with gender dysphoria. These drugs have come under an enormous amount of scrutiny in recent years, with some questioning their benefits, safety and long-term impact.

After banning the use of puberty blockers for gender treatment of people under 18, a new clinical trial in the U.K. aims to get to the bottom of those concerns.

Azeen Ghorayshi is a science and gender reporter for the New York Times.

She’ll parse through what we know and don’t know about the effects of blockers in minors, how this became a hugely divisive and politicized debate around the world, and whether this new trial could change our understanding.

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