Prof. Mihai Netea is Head of the Division of Experimental Medicine at Radboud University (Netherlands) and group leader associated with the LIMES Institute in Bonn (Germany). He was the first to describe trained immunity, the ability of the innate immune system to display enhanced responsiveness to secondary stimuli. His group has studied the epigenetic modifications and metabolic reprogramming in trained immunity, especially in the context of BCG vaccination. 

We discuss:

• Challenging dogma in immunology
• The epigenetic signatures and metabolic reprogramming occurring in trained immunity
• The evolutionary importance of trained immunity 
• Drug repurposing and nano-biologics to therapeutically target trained immunity 
• Rational use of trained immunity in vaccination strategies