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Holobiont
Ursule Demael
22 episodes
6 days ago
A podcast at the crossroads of microbiology, immunology, evolution, computational biology and more. Through informal interviews with researchers and students, I explore how biological organisms are "holobionts": super-organisms formed by a host and all of its communities of micro-organisms ( bacteria, viruses, fungi...)
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All content for Holobiont is the property of Ursule Demael and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
A podcast at the crossroads of microbiology, immunology, evolution, computational biology and more. Through informal interviews with researchers and students, I explore how biological organisms are "holobionts": super-organisms formed by a host and all of its communities of micro-organisms ( bacteria, viruses, fungi...)
Show more...
Science
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#21 The Tangled Story of H.pylori (Barry Marshall)
Holobiont
1 hour 28 minutes 41 seconds
3 years ago
#21 The Tangled Story of H.pylori (Barry Marshall)

Barry Marshall is a Professor of Clinical Microbiology at the University of Western Australia. Alongside Robin Warren, he received the Nobel Prize in Physiology or Medicine in 2005 for first showing that Helicobacter pylori bacteria, rather than acid, were the cause of stomach ulcers. For this, Marshall did a self-experiment where he ingested H.pylori and gave himself acute gastritis, establishing a first link between the infectious agent and the development of gastric disorders. 

We also embark on (a few) tangents: 

  • [00:00] The acid theory of ulcers
  • [09:20] Curiosity-driven research
  • [11:10]  Self-experiment ingesting H.pylori
  • [24:15] Non-invasive diagnostics
  • [31:00] Peer-review 
  • [40:45] Reproducibility
  • [46:15] Unanswered questions around H.pylori
  • [50:35] Bacteria as vectors 
  • [57:45] Inflammation and cancer 
  • [1:05:00] The Microbiome Revolution
  • [1:13:20] Charles Darwin
  • [1:18:45] Book recommendations
  • [1:21:10] Karry Mullis



Barry Marshall's blog: http://barryjmarshall.blogspot.com

Barry Marshall's Nobel Lecture (2005): https://www.nobelprize.org/prizes/medicine/2005/marshall/lecture/

Kary Mullis' Book: Dancing Naked in the Mind Field (1998)

Brother Surgeons: Brother Surgeons (1963) Garet Rogers




Holobiont
A podcast at the crossroads of microbiology, immunology, evolution, computational biology and more. Through informal interviews with researchers and students, I explore how biological organisms are "holobionts": super-organisms formed by a host and all of its communities of micro-organisms ( bacteria, viruses, fungi...)