This Inside Precision Medicine podcast explores how advances in DNA methylation research are transforming diabetes care. The discussion with Charlotte Ling covers motivations for focusing on methylation as valuable prognosticator of disease, the advantages of methylation risk scores (MRS) compared to polygenic risk scores (PRS), and novel gene associations linked to cardiovascular complications in diabetes. She articulates the validation needs across diverse populations, the influence of lifestyle on methylation stability, and strategies for translating these biomarkers into clinical tools. Finally, she reflects on evolving technologies, future applications of methylation biomarkers, and the potential for precision diagnostics and targeted interventions in high-risk diabetic patients.
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