In 2015 discussions began among key researchers in the field of stroke rehabilitation and recovery. This resulted in the Stroke Recovery and Rehabilitation Roundtable who met in Philadelphia, in the USA and resulted in the publication of 6 papers in the International Journal of Stroke and the Neurorehabilitation and Neural Repair journals. We are now on the second round table and things are heating up significantly in the rehabilitation and recovery space. The second published SRRR series incorporates themes of cognitive impairment, knowledge translation, an exemplar of a next generation of stroke recovery treatment trials, kinematic and kinetic movement quantification.  A major goal of the Stroke Recovery and Rehabilitation Roundtable SRRR is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In the paper, a stroke recovery trial development framework: Consensus based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable describes key issues for the next generation of stroke recovery treatment trials and presents the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development. The International Journal of Stroke is the flagship publication of the World Stroke Organization. Please do consider becoming a member and help us to fight the global burden of stroke! Visit our website here. Find the article here! Music Kool Kats by Kevin Mcleod