In this episode of Wellness Focused, Dr. Bismah Irfan explores the exciting frontier of regenerative medicine for kidney disease, including the investigational therapy Ril Perincil, presented at Kidney Week 2025.
Ril Perincil uses a patient’s own kidney cells, expanded in the lab, to create a personalized cell therapy designed to repair damaged kidney tissue. Dr. Bismah explains how this approach has shown meaningful improvements in kidney function (up to 4.5 eGFR points) in patients with stage 3–4 CKD.
She also shares her clinical insights on optimizing delivery methods, advocating for intravenous (IV) administration instead of direct kidney injections to reduce risks such as bleeding, radiation exposure, and complications, while still achieving precise targeting of damaged kidney tissue.
Dr. Bismah explains the principle of homing, where regenerative cells and exosomes naturally migrate to injured kidney tissue, releasing growth factors and anti-inflammatory molecules, and highlights how these therapies work best when combined with functional medicine protocols addressing root causes, inflammation, metabolic dysfunction, and toxin burden.
If you or a loved one has kidney disease, this episode provides a fascinating look at how personalized regenerative therapies are poised to transform kidney care safely and effectively.
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Dr. Bismah Irfan explains new regenerative medicine advances for kidney disease, including personalized kidney cell therapy, how IV administration enhances safety and effectiveness, and the role of functional medicine in supporting kidney healing.
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I’m Dr. Bismah Irfan, MD, a board-certified nephrologist and functional medicine physician. I help patients heal from kidney disease by integrating regenerative therapies with functional medicine approaches that address the root causes of inflammation, metabolic dysfunction, and tissue damage.
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Bismah Irfan, MD
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Website: https://www.drbismah.com/about/
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Produced by DrTalks