In this episode of Wellness Focused, Dr. Bismah Irfan breaks down groundbreaking 2025 research revealing how a natural plant compound—Kaempferol—protects the kidneys at a deep molecular level. Found in everyday foods like onions, kale, broccoli, and green tea, Kaempferol is proving far more powerful than previously understood.
Dr. Bismah explains how researchers used advanced network pharmacology to discover that Kaempferol targets a key pathway involved in chronic kidney disease (CKD). It binds to PISA-1, preventing activation of the HIF1-alpha pathway and blocking the metabolic shift that fuels inflammation and tissue damage. This stops the NLRP3-inflammasome, a major driver of inflammatory cell death in CKD.
She also highlights animal research showing multi-targeted benefits—from reduced oxidative stress and inflammation to improved kidney structure and function.
But most importantly, Dr. Bismah shares how simple dietary habits—like eating onions, leafy greens, cruciferous vegetables, and enjoying green tea—can help your body access this protective compound naturally. She also explains why combining these foods with healthy fats boosts absorption and effectiveness.
If you want to support your kidney health with science-backed dietary strategies, this is a must-listen episode.
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Dr. Bismah Irfan explains new 2025 research on Kaempferol, a natural plant compound found in everyday foods that protects the kidneys by blocking key inflammatory pathways and supporting metabolic balance.
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Dr. Bismah Irfan, MD
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Website: https://www.drbismah.com/about/
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