Dr. Mindy Pelz returns to explore the deeper meaning of aging, menopause, and the profound psychological and neurological transformations women undergo as they grow older. Drawing from neuroscience, anthropology, mythology, and personal experience, Mindy reframes menopause not as a decline—but as an initiation into wisdom, sovereignty, and inner authority.
We discuss the concept of the “second innocence,” the pruning and rewiring of the female brain across hormonal transitions, the grandmother hypothesis, and why modern culture fears aging women. Mindy shares how trauma, grief, solitude, and uncertainty can become gateways to resilience, neuroplasticity, and self-discovery—especially when women stop outsourcing their worth and begin listening inward.
Boost your hydration with Pique Life Tea (20% off here):
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Andrés Book Recs: https://www.knowthyselfpodcast.com/book-list
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00:00 Intro - Dr. Mindy Pelz
03:39 The return to the second innocence
08:18 What’s the purpose of menopause?
16:09 Where the shift begins
23:04 Supporting others without abandoning yourself
31:57 Being considerate vs owning others’ emotions
34:14 Ad: Pique Life
35:55 The power of solitude
43:26 Letting go
52:48 From power over to power within
56:48 The brain architecture of wisdom
1:02:24 Transformation: From a caterpillar to a butterfly
1:19:58 Fasting during menopause
1:26:35 Knowing when and how to detox
1:32:31 Healing through breathwork, EMDR, psilocybin
1:45:12 Lacking a support system
1:49:07 Closing thoughts
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Episode Resources:
Her new book: https://bookshop.org/p/books/age-like-a-girl-why-the-brain-changes-that-happen-after-40-set-you-up-for-your-best-life-yet-dr-mindy-pelz/1d7c0fe95ab52c4f?ean=9781401975562&next=t
https://www.instagram.com/dr.mindypelz
https://www.drmindypelz.com/
https://www.instagram.com/andreduqum/
https://www.instagram.com/knowthyself/
https://www.youtube.com/@knowthyselfpodcast
https://www.knowthyselfpodcast.com