Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Justin Strickland, Johns Hopkins University School of Medicine. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Justin Strickland, Associate Professor of Psychiatry and Behavioral Sciences, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine.
In the October 2025 podcast Justin Strickland talks about his work on e-cigarette withdrawal syndrome presented at the 13th Annual Vermont Center on Behavior and Health Conference, held in Vermont, USA. Justin is a behavioural pharmacologist working with substance use and substance use disorder. His research applies behavioural economic methods to evaluate choice and decision-making mechanisms that may underlie substance use and identify targets for their reduction. Justin begins by describing behavioral economics and how our environment and context shape the decisions we make, for example, how the cost of goods can influence patterns of consumption. As a relatively new class of products less is known about e-cigarette withdrawal than tobacco withdrawal syndrome. Justin describes his ongoing study of e-cigarette withdrawal syndrome among people who have exclusively used e-cigarettes. Participants stay in a residential unit for one week, where their behaviour, physiology and other measures, including their nicotine clearance, are measured. Preliminary findings indicate that participants do experience withdrawal to e-cigarettes, for example cravings that reduce over time. Looking to the future he calls for longer-term trials to observe behaviour and to explore predictors of complete cessation. Such research could inform the development of more effective behavioral interventions or pharmacological treatments to support individuals experiencing e-cigarette withdrawal.
This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches.
Our searches for the EC for smoking cessation review carried out on 1st October 2025 found: 1 new study (10.18332/852498tivblr); 2 ongoing new studies (ISRCTN12504090, 10.1177/29768357251337050); and 4 linked reports (10.1016/j.ypmed.2025.108414, 10.1037/pha0000803, 10.1093/ntr/ntaf200, 10.1101/2024.06.21.24309282).
Our search for our interventions for quitting vaping review carried out 1st October 2025 found: 1 new ongoing study (10.3389/fpubh.2025.1618341).
For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1
For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full
For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full
This podcast is supported by Cancer Research UK.
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Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Justin Strickland, Johns Hopkins University School of Medicine. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Justin Strickland, Associate Professor of Psychiatry and Behavioral Sciences, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine.
In the October 2025 podcast Justin Strickland talks about his work on e-cigarette withdrawal syndrome presented at the 13th Annual Vermont Center on Behavior and Health Conference, held in Vermont, USA. Justin is a behavioural pharmacologist working with substance use and substance use disorder. His research applies behavioural economic methods to evaluate choice and decision-making mechanisms that may underlie substance use and identify targets for their reduction. Justin begins by describing behavioral economics and how our environment and context shape the decisions we make, for example, how the cost of goods can influence patterns of consumption. As a relatively new class of products less is known about e-cigarette withdrawal than tobacco withdrawal syndrome. Justin describes his ongoing study of e-cigarette withdrawal syndrome among people who have exclusively used e-cigarettes. Participants stay in a residential unit for one week, where their behaviour, physiology and other measures, including their nicotine clearance, are measured. Preliminary findings indicate that participants do experience withdrawal to e-cigarettes, for example cravings that reduce over time. Looking to the future he calls for longer-term trials to observe behaviour and to explore predictors of complete cessation. Such research could inform the development of more effective behavioral interventions or pharmacological treatments to support individuals experiencing e-cigarette withdrawal.
This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches.
Our searches for the EC for smoking cessation review carried out on 1st October 2025 found: 1 new study (10.18332/852498tivblr); 2 ongoing new studies (ISRCTN12504090, 10.1177/29768357251337050); and 4 linked reports (10.1016/j.ypmed.2025.108414, 10.1037/pha0000803, 10.1093/ntr/ntaf200, 10.1101/2024.06.21.24309282).
Our search for our interventions for quitting vaping review carried out 1st October 2025 found: 1 new ongoing study (10.3389/fpubh.2025.1618341).
For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1
For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full
For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full
This podcast is supported by Cancer Research UK.
Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Reto Auer, Bern University, Switzerland. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Reto Auer, primary care physician and clinical researcher from the Institute of Primary Health Care (BIHAM), University of Bern. Reto Auer is Head of the Substance Use Unit, where he leads a variety of research projects, including a large randomized controlled trial designed to test the efficacy, safety and toxicology of nicotine e-cigarettes.
Jamie Hartmann-Boyce interviews Reto Auer about his new study published in the New England Journal of Medicine ‘Electronic nicotine delivery systems for smoking cessation’. This trial randomized 1246 participants: 622 to free e-cigarettes and e-liquids, standard-of-care smoking-cessation counselling, and optional (not free) nicotine-replacement therapy; and 624 participants to a control group, which received standard counselling and a voucher, which they could use for any purpose, including nicotine-replacement therapy. This study was funded by the Swiss National Science Foundation and others and registered as ESTxENDS NCT03589989. The percentage of participants with validated continuous abstinence from tobacco smoking was 28.9% in the intervention group and 16.3% in the control group (relative risk, 1.77; 95% confidence interval, 1.43 to 2.20). The study concluded that adding e-cigarettes to standard smoking-cessation counselling resulted in greater abstinence from tobacco use among smokers than smoking-cessation counselling alone.
DOI: 10.1056/NEJMoa2308815
This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.
Our literature searches carried out on 1st February found the following
1 new study by Lin 2024 (Lin, H-X, Liu Z, Hajek P, Zhang W-T, Wu Y, Zhu B-C, Liu H-H, Xiang Q, Zhang Y, Li S-B, Pesola F, Wang Y-Y, Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial, JAMA internal medicine / 2024;(101589534).)
3 new ongoing studies:
NCT06169813, E-cigarette Harm Reduction Among PLWHA in South Africa.
ISRCTN14068059, E-cigarettes for smoking cessation and reduction in people with a mental illness.
Hameed A, Malik D, Clinical study protocol on electronic cigarettes and nicotine pouches for smoking cessation in Pakistan: a randomized controlled trial, Trials / 2024;25(1):9
3 papers linked to studies included in the review:
Scheibein F, McGirr K, Morrison A, Roche W, Wells JSG, Correction to: an exploratory non-randomized study of a 3-month electronic nicotine delivery system (ENDS) intervention with people
accessing a homeless supported temporary accommodation service (STA) in Ireland, Harm reduction journal 2021;18(1):113
Pesola F, Smith KM, Phillips-Waller A, Przulj D, Griffiths C, Walton R, McRobbie H, Coleman T, Lewis S, Whitemore R, Clark M, Ussher M, Sinclair L, Seager E, Cooper S, Bauld L, Naughton F, Sasieni P, Manyonda I, Hajek P, Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial, Addiction (Abingdon, England) / 2024
Trigg J, Rich J, Williams E, Gartner CE, Guillaumier A, Bonevski B, Perspectives on limiting tobacco access and supporting access to nicotine vaping products among clients of residential drug and alcohol treatment services in Australia, Tobacco control 2023
For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1
Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Reto Auer, primary care physician and clinical researcher from the Institute of Primary Health Care (BIHAM), University of Bern. Reto Auer is Head of the Substance Use Unit, where he leads a variety of research projects, including a large randomized controlled trial designed to test the efficacy, safety and toxicology of nicotine e-cigarettes.
Jamie Hartmann-Boyce interviews Reto Auer about his new study published in the New England Journal of Medicine ‘Electronic nicotine delivery systems for smoking cessation’. This trial randomized 1246 participants: 622 to free e-cigarettes and e-liquids, standard-of-care smoking-cessation counselling, and optional (not free) nicotine-replacement therapy; and 624 participants to a control group, which received standard counselling and a voucher, which they could use for any purpose, including nicotine-replacement therapy. This study was funded by the Swiss National Science Foundation and others and registered as ESTxENDS NCT03589989. The percentage of participants with validated continuous abstinence from tobacco smoking was 28.9% in the intervention group and 16.3% in the control group (relative risk, 1.77; 95% confidence interval, 1.43 to 2.20). The study concluded that adding e-cigarettes to standard smoking-cessation counselling resulted in greater abstinence from tobacco use among smokers than smoking-cessation counselling alone.
DOI: 10.1056/NEJMoa2308815
This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.
Our literature searches carried out on 1st February found the following
1 new study by Lin 2024 (Lin, H-X, Liu Z, Hajek P, Zhang W-T, Wu Y, Zhu B-C, Liu H-H, Xiang Q, Zhang Y, Li S-B, Pesola F, Wang Y-Y, Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial, JAMA internal medicine / 2024;(101589534).)
3 new ongoing studies:
NCT06169813, E-cigarette Harm Reduction Among PLWHA in South Africa.
ISRCTN14068059, E-cigarettes for smoking cessation and reduction in people with a mental illness.
Hameed A, Malik D, Clinical study protocol on electronic cigarettes and nicotine pouches for smoking cessation in Pakistan: a randomized controlled trial, Trials / 2024;25(1):9
3 papers linked to studies included in the review:
Scheibein F, McGirr K, Morrison A, Roche W, Wells JSG, Correction to: an exploratory non-randomized study of a 3-month electronic nicotine delivery system (ENDS) intervention with people accessing a homeless supported temporary accommodation service (STA) in Ireland, Harm reduction journal 2021;18(1):113
Pesola F, Smith KM, Phillips-Waller A, Przulj D, Griffiths C, Walton R, McRobbie H, Coleman T, Lewis S, Whitemore R, Clark M, Ussher M, Sinclair L, Seager E, Cooper S, Bauld L, Naughton F, Sasieni P, Manyonda I, Hajek P, Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial, Addiction (Abingdon, England) / 2024
Trigg J, Rich J, Williams E, Gartner CE, Guillaumier A, Bonevski B, Perspectives on limiting tobacco access and supporting access to nicotine vaping products among clients of residential drug and alcohol treatment services in Australia, Tobacco control 2023
For further details see our webpage under 'Monthly search findings':
https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1
For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full
This podcast is supported by Cancer Research UK.
This podcast is supported by Cancer Research UK. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/
Let's talk e-cigarettes
Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Justin Strickland, Johns Hopkins University School of Medicine. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Justin Strickland, Associate Professor of Psychiatry and Behavioral Sciences, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine.
In the October 2025 podcast Justin Strickland talks about his work on e-cigarette withdrawal syndrome presented at the 13th Annual Vermont Center on Behavior and Health Conference, held in Vermont, USA. Justin is a behavioural pharmacologist working with substance use and substance use disorder. His research applies behavioural economic methods to evaluate choice and decision-making mechanisms that may underlie substance use and identify targets for their reduction. Justin begins by describing behavioral economics and how our environment and context shape the decisions we make, for example, how the cost of goods can influence patterns of consumption. As a relatively new class of products less is known about e-cigarette withdrawal than tobacco withdrawal syndrome. Justin describes his ongoing study of e-cigarette withdrawal syndrome among people who have exclusively used e-cigarettes. Participants stay in a residential unit for one week, where their behaviour, physiology and other measures, including their nicotine clearance, are measured. Preliminary findings indicate that participants do experience withdrawal to e-cigarettes, for example cravings that reduce over time. Looking to the future he calls for longer-term trials to observe behaviour and to explore predictors of complete cessation. Such research could inform the development of more effective behavioral interventions or pharmacological treatments to support individuals experiencing e-cigarette withdrawal.
This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches.
Our searches for the EC for smoking cessation review carried out on 1st October 2025 found: 1 new study (10.18332/852498tivblr); 2 ongoing new studies (ISRCTN12504090, 10.1177/29768357251337050); and 4 linked reports (10.1016/j.ypmed.2025.108414, 10.1037/pha0000803, 10.1093/ntr/ntaf200, 10.1101/2024.06.21.24309282).
Our search for our interventions for quitting vaping review carried out 1st October 2025 found: 1 new ongoing study (10.3389/fpubh.2025.1618341).
For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1
For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full
For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full
This podcast is supported by Cancer Research UK.
