Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Ian Pope. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Ian Pope, an emergency medicine physician and honorary associate professor at Norwich Medical School, about his new trial, which he co leads with Professor Caitlin Notley from the University of East Anglia. The new trial is the COSTED trial, the Cessation of Smoking Trial in the Emergency Department and funded by the British National Institutes of Health Research. This is a multi-centre randomised controlled trial, based in 6 emergency departments around the UK. This study tested the real-world effectiveness of an emergency department based smoking cessation intervention that included provision of an e-cigarette starter kit compared to usual care. (ClinicalTrial.gov:NCT04854616). Adults who smoke tobacco and were attending one of six EDs across the UK were randomised to either control (in which case they were given written information about stop smoking services) or intervention (brief smoking cessation intervention, provision of an e-cigarette starter kit, and referral to stop smoking services). Both groups were followed up 1, 3 and 6 months after randomisation. Smoking abstinence was biochemically verified at 6 months. There were over a thousand participants and biochemically verified smoking cessation rate of 7.2% in the intervention group 4.1% in the control group. The study found that it was feasible to implement a smoking cessation intervention in EDs with dedicated staff time to deliver the intervention and that EDs may represent an excellent opportunity to engage hard to reach smokers. Pope I, Notley C, Boyle A, Results of the cessation of smoking trial in the emergency department (COSTED), Emergency Medicine Journal / 2023;40(12):873-874 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st March found the following 1 new study: Hoeppner BB, Eddie D, Schick M, Hoeppner SS, Kelly L, Kelly JF, Feasibility of and reactivity to ecological momentary assessment (EMA) during electronic cigarette use initiation in adults who smoke daily: MASKED FOR REVIEW, European Journal of Psychiatry / 2024;38(3):100247. 10.1016/j.ejpsy.2023.100247 3 papers linked to studies included in the review: Auer R, Schoeni A, Humair J-P, Jacot-Sadowski I, Berlin I, Stuber MJ, Haller ML, Tango RC, Frei A, Strassmann A, Bruggmann P, Baty F, Brutsche M, Tal K, Baggio S, Jakob J, Sambiagio N, Hopf NB, Feller M, Rodondi N, Berthet A, Electronic Nicotine-Delivery Systems for Smoking Cessation, The New England journal of medicine / 2024;390(7):601-610. 10.1056/NEJMoa2308815 Piper ME, Schlam TR, Donny EC, Kobinsky K, Matthews J, Piasecki TM, Jorenby DE, The Impact of Three Alternate Nicotine-Delivery Products on Combusted Cigarette Use: A Randomized Controlled Trial, Nicotine & Tobacco Research, 2024;, ntae014, 10.1093/ntr/ntae014 Correction to Yingst: Changes in Nicotine Dependence Among Smokers Using Electronic Cigarettes to Reduce Cigarette Smoking in a Randomized Controlled Trial, Nicotine & Tobacco Research, 2023;, ntad229, 10.1093/ntr/ntad229 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/