IAS Visiting Fellow Dr Changsheng Wu delivers a seminar on their research - The rapid aging of populations and COVID-19 pandemic have exposed critical healthcare shortcomings. Traditional healthcare remains offline and reactive, with intermittent clinical monitoring. Recent advancements in smart materials, wearables, AI, and IoT enable continuous, personalized digital health solutions. However, challenges persist in achieving advanced monitoring modalities and accessibility. This talk presents our progress in developing cost-effective, accessible sensing technologies for ambulatory monitoring of deep-tissue signals. I will introduce wireless, flexible near-infrared spectroscopy (NIRS) devices for measuring local hemodynamics and tissue oxygenation, mechano-acoustic sensors to decode tissue mechanics, and radio-frequency metamaterial sensors for non-contact vital sign detection. These accessible devices, powered by advanced signal processing, enable unique capabilities including ambulatory monitoring of hemodynamics and tissue stiffness alongside non-contact physiological assessment, offering promising directions toward pervasive healthcare. For more information about the IAS, please visit - https://www.lboro.ac.uk/research/ias