At the start of October, lots of the Unit’s clinical trials methodology researchers travelled to Edinburgh, for the 7th International Clinical Trials Methodology Conference (ICTMC).
ICTMC is the largest academic-led conference on clinical trials, bringing together trialists from across the globe to present their latest work in trials methodology. This year's conference featured a wide variety of workshops, talks and poster presentations from MRC Clinical Trials Unit researchers.
In this latest episode of the Trial Talk podcast, four of the Unit’s early career researchers discuss the work they presented at ICTMC 2024.
Gideon Darko Asamoah tells us how he will deliver a core outcome set for trials in severe malaria; Jingyi Xuan describes her project addressing intercurrent events in platform trials; Dongquan Bi discusses the effects of different cluster sizes in cluster trials; and finally, Kate Roberts explains how she aims to improve the wording around consent for accessing trial participants' healthcare records.
For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk
For more information and to access the transcript: https://bit.ly/4f9grVi
As a listener, your opinion is very valuable to us. Please help us to improve the podcast in future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g
More resources:
• Developing a core outcome set for severe malaria trials poster: https://www.mrcctu.ucl.ac.uk/posters/identifying-a-comprehensive-long-list-of-outcomes-for-developing-a-core-outcome-set-for-severe-malaria-treatment-trials-a-systematic-review-and-inclusion-of-outcomes-important-to-patients-and-caregivers/
• Specifying estimands and estimators in trials with complex designs poster: https://www.mrcctu.ucl.ac.uk/posters/specifying-estimands-and-estimators-in-trials-with-complex-designs/
• Demystifying estimands in cluster-randomised trials paper in Statistical Methods in Medical Research: https://journals.sagepub.com/doi/10.1177/09622802241254197
• Estimands in cluster-randomised trials paper in International Journal of Epidemiology: https://academic.oup.com/ije/article/52/1/107/6644521
• Current practice around the use of estimands in cluster randomised trials, and the impact of informative cluster size on inference poster: https://www.mrcctu.ucl.ac.uk/posters/current-practice-around-the-use-of-estimands-in-cluster-randomised-trials-and-the-impacts-of-informative-cluster-size-on-inferences/
• ICTMC 2024 Poster 167 – A rap song (Lyrics by Dongquan Bi, beat by David Fitzgerald): https://youtu.be/s7qZ5TnOlWU?si=iXwfFfSAWwJ-fAmk
• CrossWord poster: https://www.mrcctu.ucl.ac.uk/posters/crossword-consent-to-access-and-use-healthcare-systems-data-for-clinical-trials-a-review-of-current-language-in-participant-facing-materials/
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At the start of October, lots of the Unit’s clinical trials methodology researchers travelled to Edinburgh, for the 7th International Clinical Trials Methodology Conference (ICTMC).
ICTMC is the largest academic-led conference on clinical trials, bringing together trialists from across the globe to present their latest work in trials methodology. This year's conference featured a wide variety of workshops, talks and poster presentations from MRC Clinical Trials Unit researchers.
In this latest episode of the Trial Talk podcast, four of the Unit’s early career researchers discuss the work they presented at ICTMC 2024.
Gideon Darko Asamoah tells us how he will deliver a core outcome set for trials in severe malaria; Jingyi Xuan describes her project addressing intercurrent events in platform trials; Dongquan Bi discusses the effects of different cluster sizes in cluster trials; and finally, Kate Roberts explains how she aims to improve the wording around consent for accessing trial participants' healthcare records.
For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk
For more information and to access the transcript: https://bit.ly/4f9grVi
As a listener, your opinion is very valuable to us. Please help us to improve the podcast in future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g
More resources:
• Developing a core outcome set for severe malaria trials poster: https://www.mrcctu.ucl.ac.uk/posters/identifying-a-comprehensive-long-list-of-outcomes-for-developing-a-core-outcome-set-for-severe-malaria-treatment-trials-a-systematic-review-and-inclusion-of-outcomes-important-to-patients-and-caregivers/
• Specifying estimands and estimators in trials with complex designs poster: https://www.mrcctu.ucl.ac.uk/posters/specifying-estimands-and-estimators-in-trials-with-complex-designs/
• Demystifying estimands in cluster-randomised trials paper in Statistical Methods in Medical Research: https://journals.sagepub.com/doi/10.1177/09622802241254197
• Estimands in cluster-randomised trials paper in International Journal of Epidemiology: https://academic.oup.com/ije/article/52/1/107/6644521
• Current practice around the use of estimands in cluster randomised trials, and the impact of informative cluster size on inference poster: https://www.mrcctu.ucl.ac.uk/posters/current-practice-around-the-use-of-estimands-in-cluster-randomised-trials-and-the-impacts-of-informative-cluster-size-on-inferences/
• ICTMC 2024 Poster 167 – A rap song (Lyrics by Dongquan Bi, beat by David Fitzgerald): https://youtu.be/s7qZ5TnOlWU?si=iXwfFfSAWwJ-fAmk
• CrossWord poster: https://www.mrcctu.ucl.ac.uk/posters/crossword-consent-to-access-and-use-healthcare-systems-data-for-clinical-trials-a-review-of-current-language-in-participant-facing-materials/
Octopus (part 2): Introducing the trial with Jeremy Chataway
MRC CTU Podcasts
24 minutes 10 seconds
2 years ago
Octopus (part 2): Introducing the trial with Jeremy Chataway
Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS), which is designed and run by the MRC Clinical Trials Unit at UCL. Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recruiting participants for the next few years.
The podcast mini-series will explore the trial from different perspectives by talking to neurologists, MS experts and people affected by MS.
Part 2 of the series explores our Octopus trial in depth. Professor Jeremy Chataway, lead investigator of Octopus, discusses its novel design, the treatments it will test, and the criteria for people to take part. He also explains the data researchers will collect and analyse to find out if a treatment is working.
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For more information and to access the transcript: bit.ly/3S6FKP4
For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk
As a listener, your opinion is very valuable to us. Please help us to improve the podcast in the future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g
MRC CTU Podcasts
At the start of October, lots of the Unit’s clinical trials methodology researchers travelled to Edinburgh, for the 7th International Clinical Trials Methodology Conference (ICTMC).
ICTMC is the largest academic-led conference on clinical trials, bringing together trialists from across the globe to present their latest work in trials methodology. This year's conference featured a wide variety of workshops, talks and poster presentations from MRC Clinical Trials Unit researchers.
In this latest episode of the Trial Talk podcast, four of the Unit’s early career researchers discuss the work they presented at ICTMC 2024.
Gideon Darko Asamoah tells us how he will deliver a core outcome set for trials in severe malaria; Jingyi Xuan describes her project addressing intercurrent events in platform trials; Dongquan Bi discusses the effects of different cluster sizes in cluster trials; and finally, Kate Roberts explains how she aims to improve the wording around consent for accessing trial participants' healthcare records.
For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk
For more information and to access the transcript: https://bit.ly/4f9grVi
As a listener, your opinion is very valuable to us. Please help us to improve the podcast in future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g
More resources:
• Developing a core outcome set for severe malaria trials poster: https://www.mrcctu.ucl.ac.uk/posters/identifying-a-comprehensive-long-list-of-outcomes-for-developing-a-core-outcome-set-for-severe-malaria-treatment-trials-a-systematic-review-and-inclusion-of-outcomes-important-to-patients-and-caregivers/
• Specifying estimands and estimators in trials with complex designs poster: https://www.mrcctu.ucl.ac.uk/posters/specifying-estimands-and-estimators-in-trials-with-complex-designs/
• Demystifying estimands in cluster-randomised trials paper in Statistical Methods in Medical Research: https://journals.sagepub.com/doi/10.1177/09622802241254197
• Estimands in cluster-randomised trials paper in International Journal of Epidemiology: https://academic.oup.com/ije/article/52/1/107/6644521
• Current practice around the use of estimands in cluster randomised trials, and the impact of informative cluster size on inference poster: https://www.mrcctu.ucl.ac.uk/posters/current-practice-around-the-use-of-estimands-in-cluster-randomised-trials-and-the-impacts-of-informative-cluster-size-on-inferences/
• ICTMC 2024 Poster 167 – A rap song (Lyrics by Dongquan Bi, beat by David Fitzgerald): https://youtu.be/s7qZ5TnOlWU?si=iXwfFfSAWwJ-fAmk
• CrossWord poster: https://www.mrcctu.ucl.ac.uk/posters/crossword-consent-to-access-and-use-healthcare-systems-data-for-clinical-trials-a-review-of-current-language-in-participant-facing-materials/
