At the start of October, lots of the Unit’s clinical trials methodology researchers travelled to Edinburgh, for the 7th International Clinical Trials Methodology Conference (ICTMC).
ICTMC is the largest academic-led conference on clinical trials, bringing together trialists from across the globe to present their latest work in trials methodology. This year's conference featured a wide variety of workshops, talks and poster presentations from MRC Clinical Trials Unit researchers.
In this latest episode of the Trial Talk podcast, four of the Unit’s early career researchers discuss the work they presented at ICTMC 2024.
Gideon Darko Asamoah tells us how he will deliver a core outcome set for trials in severe malaria; Jingyi Xuan describes her project addressing intercurrent events in platform trials; Dongquan Bi discusses the effects of different cluster sizes in cluster trials; and finally, Kate Roberts explains how she aims to improve the wording around consent for accessing trial participants' healthcare records.
For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk
For more information and to access the transcript: https://bit.ly/4f9grVi
As a listener, your opinion is very valuable to us. Please help us to improve the podcast in future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g
More resources:
• Developing a core outcome set for severe malaria trials poster: https://www.mrcctu.ucl.ac.uk/posters/identifying-a-comprehensive-long-list-of-outcomes-for-developing-a-core-outcome-set-for-severe-malaria-treatment-trials-a-systematic-review-and-inclusion-of-outcomes-important-to-patients-and-caregivers/
• Specifying estimands and estimators in trials with complex designs poster: https://www.mrcctu.ucl.ac.uk/posters/specifying-estimands-and-estimators-in-trials-with-complex-designs/
• Demystifying estimands in cluster-randomised trials paper in Statistical Methods in Medical Research: https://journals.sagepub.com/doi/10.1177/09622802241254197
• Estimands in cluster-randomised trials paper in International Journal of Epidemiology: https://academic.oup.com/ije/article/52/1/107/6644521
• Current practice around the use of estimands in cluster randomised trials, and the impact of informative cluster size on inference poster: https://www.mrcctu.ucl.ac.uk/posters/current-practice-around-the-use-of-estimands-in-cluster-randomised-trials-and-the-impacts-of-informative-cluster-size-on-inferences/
• ICTMC 2024 Poster 167 – A rap song (Lyrics by Dongquan Bi, beat by David Fitzgerald): https://youtu.be/s7qZ5TnOlWU?si=iXwfFfSAWwJ-fAmk
• CrossWord poster: https://www.mrcctu.ucl.ac.uk/posters/crossword-consent-to-access-and-use-healthcare-systems-data-for-clinical-trials-a-review-of-current-language-in-participant-facing-materials/
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At the start of October, lots of the Unit’s clinical trials methodology researchers travelled to Edinburgh, for the 7th International Clinical Trials Methodology Conference (ICTMC).
ICTMC is the largest academic-led conference on clinical trials, bringing together trialists from across the globe to present their latest work in trials methodology. This year's conference featured a wide variety of workshops, talks and poster presentations from MRC Clinical Trials Unit researchers.
In this latest episode of the Trial Talk podcast, four of the Unit’s early career researchers discuss the work they presented at ICTMC 2024.
Gideon Darko Asamoah tells us how he will deliver a core outcome set for trials in severe malaria; Jingyi Xuan describes her project addressing intercurrent events in platform trials; Dongquan Bi discusses the effects of different cluster sizes in cluster trials; and finally, Kate Roberts explains how she aims to improve the wording around consent for accessing trial participants' healthcare records.
For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk
For more information and to access the transcript: https://bit.ly/4f9grVi
As a listener, your opinion is very valuable to us. Please help us to improve the podcast in future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g
More resources:
• Developing a core outcome set for severe malaria trials poster: https://www.mrcctu.ucl.ac.uk/posters/identifying-a-comprehensive-long-list-of-outcomes-for-developing-a-core-outcome-set-for-severe-malaria-treatment-trials-a-systematic-review-and-inclusion-of-outcomes-important-to-patients-and-caregivers/
• Specifying estimands and estimators in trials with complex designs poster: https://www.mrcctu.ucl.ac.uk/posters/specifying-estimands-and-estimators-in-trials-with-complex-designs/
• Demystifying estimands in cluster-randomised trials paper in Statistical Methods in Medical Research: https://journals.sagepub.com/doi/10.1177/09622802241254197
• Estimands in cluster-randomised trials paper in International Journal of Epidemiology: https://academic.oup.com/ije/article/52/1/107/6644521
• Current practice around the use of estimands in cluster randomised trials, and the impact of informative cluster size on inference poster: https://www.mrcctu.ucl.ac.uk/posters/current-practice-around-the-use-of-estimands-in-cluster-randomised-trials-and-the-impacts-of-informative-cluster-size-on-inferences/
• ICTMC 2024 Poster 167 – A rap song (Lyrics by Dongquan Bi, beat by David Fitzgerald): https://youtu.be/s7qZ5TnOlWU?si=iXwfFfSAWwJ-fAmk
• CrossWord poster: https://www.mrcctu.ucl.ac.uk/posters/crossword-consent-to-access-and-use-healthcare-systems-data-for-clinical-trials-a-review-of-current-language-in-participant-facing-materials/
The REFINE trial: How can we improve the way we give cancer immunotherapy?
MRC CTU Podcasts
16 minutes 57 seconds
2 years ago
The REFINE trial: How can we improve the way we give cancer immunotherapy?
Immunotherapy drugs fight cancer by helping the immune system recognise and attack cancer cells. These drugs have revolutionised cancer treatment over the last decade, improving survival for many people with different types of cancer. However, researchers are still unsure of the best way to give immunotherapy, which can come with unpredictable side effects.
In this episode, Clinical Fellow Sophie Merrick discusses how the REFINE trial hopes to address this problem, by testing if giving immunotherapy less frequently can still treat the cancer effectively, whilst improving the quality of life for patients, reducing side effects and costs.
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Further information is available on the REFINE study page at www.mrcctu.ucl.ac.uk
For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk
For more information and to access the transcript: https://bit.ly/3DgIDE2
As a listener, your opinion is very valuable to us. Please help us to improve the podcast in future by filling in this short survey: https://forms.office.com/e/PjfjQ5Mn6g
MRC CTU Podcasts
At the start of October, lots of the Unit’s clinical trials methodology researchers travelled to Edinburgh, for the 7th International Clinical Trials Methodology Conference (ICTMC).
ICTMC is the largest academic-led conference on clinical trials, bringing together trialists from across the globe to present their latest work in trials methodology. This year's conference featured a wide variety of workshops, talks and poster presentations from MRC Clinical Trials Unit researchers.
In this latest episode of the Trial Talk podcast, four of the Unit’s early career researchers discuss the work they presented at ICTMC 2024.
Gideon Darko Asamoah tells us how he will deliver a core outcome set for trials in severe malaria; Jingyi Xuan describes her project addressing intercurrent events in platform trials; Dongquan Bi discusses the effects of different cluster sizes in cluster trials; and finally, Kate Roberts explains how she aims to improve the wording around consent for accessing trial participants' healthcare records.
For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk
For more information and to access the transcript: https://bit.ly/4f9grVi
As a listener, your opinion is very valuable to us. Please help us to improve the podcast in future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g
More resources:
• Developing a core outcome set for severe malaria trials poster: https://www.mrcctu.ucl.ac.uk/posters/identifying-a-comprehensive-long-list-of-outcomes-for-developing-a-core-outcome-set-for-severe-malaria-treatment-trials-a-systematic-review-and-inclusion-of-outcomes-important-to-patients-and-caregivers/
• Specifying estimands and estimators in trials with complex designs poster: https://www.mrcctu.ucl.ac.uk/posters/specifying-estimands-and-estimators-in-trials-with-complex-designs/
• Demystifying estimands in cluster-randomised trials paper in Statistical Methods in Medical Research: https://journals.sagepub.com/doi/10.1177/09622802241254197
• Estimands in cluster-randomised trials paper in International Journal of Epidemiology: https://academic.oup.com/ije/article/52/1/107/6644521
• Current practice around the use of estimands in cluster randomised trials, and the impact of informative cluster size on inference poster: https://www.mrcctu.ucl.ac.uk/posters/current-practice-around-the-use-of-estimands-in-cluster-randomised-trials-and-the-impacts-of-informative-cluster-size-on-inferences/
• ICTMC 2024 Poster 167 – A rap song (Lyrics by Dongquan Bi, beat by David Fitzgerald): https://youtu.be/s7qZ5TnOlWU?si=iXwfFfSAWwJ-fAmk
• CrossWord poster: https://www.mrcctu.ucl.ac.uk/posters/crossword-consent-to-access-and-use-healthcare-systems-data-for-clinical-trials-a-review-of-current-language-in-participant-facing-materials/
