This podcast episode reviews a 2001 study published in the American Journal of Physiology, Endocrinology, and Metabolism by Dr. Bhasin, focusing on the optimal testosterone dose for men. The study involved 65 young men whose natural testosterone was suppressed before administering varying weekly doses of testosterone cypionate (25-600mg) for 20 weeks, with no exercise or dietary changes allowed. The research aimed to evaluate the impact of different doses on hormone levels, body composition, muscle strength, and sexual function, revealing that while higher doses increased muscle mass and strength, they also led to negative effects like decreased HDL cholesterol and increased hematocrit, whereas lower doses could be ineffective or even detrimental. Vergel highlights the study’s unique approach and its relevance to understanding testosterone replacement, acknowledging that such comprehensive research is rare due to ethical and logistical challenges.