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Physician focused on the science of preventative health, aging, and athletic performance.
How to Find Metabolic Dysfunction EARLY - Longevity & Healthspan
Nick Sterling, MD, PhD
12 minutes 51 seconds
1 month ago
How to Find Metabolic Dysfunction EARLY - Longevity & Healthspan
Spotting Metabolic Dysfunction Early: LP-IR, Waist-to-Hip, Uric Acid & More. In this episode, we cover practical ways to spot early metabolic dysfunction. We walk through the LP-IR (lipoprotein insulin resistance) index and what changing lipid particle patterns reveal, then show how to measure waist-to-hip ratio correctly and interpret risk thresholds. We also touch on where magnesium fits (and its small effects on blood pressure), how to read kidney function more accurately by pairing creatinine with cystatin C, what rising uric acid can signal (including ties to fructose intake and blood pressure), and simple lab/imaging clues of hepatic steatosis/NAFLD.HighlightsLP-IR flags insulin resistance before glucose markers shift.Waist-to-hip ratio is a strong visceral fat proxy.Creatinine + cystatin C improves eGFR accuracy.Uric acid links fructose intake to higher blood pressure.Chapter Markers00:00 Intro: avoid health “icebergs”00:00:41 Metabolic dysfunction 10100:01:26 LP-IR (lipoprotein insulin resistance) explained00:02:22 Triglycerides, VLDL & HDL in insulin resistance00:03:28 Small dense LDL & LP-IR00:04:51 Waist-to-hip ratio: measure & cutoffs00:06:14 Magnesium: insulin sensitivity & small BP effects00:06:47 Kidney function: creatinine + cystatin C (combined eGFR)00:09:06 Uric acid, fructose & blood pressure00:11:08 Liver fat (NAFLD): labs & imagingSpotify Channel:https://podcasters.spotify.com/pod/show/sterlingmdphd/Social & Website:Instagram - https://www.instagram.com/sterlingmdphdX - https://x.com/sterlingmdphdFacebook - / sterlingmdphdNewsletter - http://eepurl.com/hQpdqTApple Podcasts: https://apple.co/3y438C9References & Show Notes:http://www.nicksterling.com/This content is not medical advice, is for general information purposes only,and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. This content is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit http://nicksterling.com/terms for full Terms of Use.
Nick Sterling, MD, PhD
Physician focused on the science of preventative health, aging, and athletic performance.
