S1E10 | Cecilia Rodriguez-Furlan | Polarized IRK and KOIN

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No Time To Read

Arif Ashraf

30 episodes

2 weeks ago

Arif, plant biologist and host of the podcast, will talk to lead author of a recently published plant biology paper. The guest will simply explain the story of the publication, answer questions from the host, and share personal experience and details related to the article. As an audience, you will tune in to the episode with an expectation that you will know the story of the paper without reading it. Besides, you can keep listening the podcast during your experiment, walking outside, in your car and wherever possible.

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Life Sciences

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S1E10 | Cecilia Rodriguez-Furlan | Polarized IRK and KOIN

No Time To Read

29 minutes 28 seconds

3 years ago

S1E10 | Cecilia Rodriguez-Furlan | Polarized IRK and KOIN

Article: Distinct mechanisms orchestrate the contra-polarity of IRK and KOIN, two LRR-receptor-kinases controlling root cell division
Journal: Nature Communications
Year: 2022
Guest: Cecilia Rodriguez-Furlan
Host: Arif Ashraf

Abstract

In plants, cell polarity plays key roles in coordinating developmental processes. Despite the characterization of several polarly localized plasma membrane proteins, the mechanisms connecting protein dynamics with cellular functions often remain unclear. Here, we introduce a polarized receptor, KOIN, that restricts cell divisions in the Arabidopsis root meristem. In the endodermis, KOIN polarity is opposite to IRK, a receptor that represses endodermal cell divisions. Their contra-polar localization facilitates dissection of polarity mechanisms and the links between polarity and function. We find that IRK and KOIN are recognized, sorted, and secreted through distinct pathways. IRK extracellular domains determine its polarity and partially rescue the mutant phenotype, whereas KOIN’s extracellular domains are insufficient for polar sorting and function. Endodermal expression of an IRK/KOIN chimera generates non-cell-autonomous misregulation of root cell divisions that impacts patterning. Altogether, we reveal two contrasting mechanisms determining these receptors’ polarity and link their polarity to cell divisions in root tissue patterning.

Cover art design and audio editing: Ragib Anjum