In this episode of Off Label, we unpack a paper by Dr. Steve Rondeau that tackles one of the biggest challenges in mental health care: diagnostic heterogeneity. When two patients present with the same symptoms but have entirely different underlying conditions, misdiagnosis becomes almost inevitable—and treatment suffers. The paper explains how overlapping symptoms, frequent comorbidities, and decades of generalized diagnostic frameworks contribute to high error rates and growing patient distr...
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In this episode of Off Label, we unpack a paper by Dr. Steve Rondeau that tackles one of the biggest challenges in mental health care: diagnostic heterogeneity. When two patients present with the same symptoms but have entirely different underlying conditions, misdiagnosis becomes almost inevitable—and treatment suffers. The paper explains how overlapping symptoms, frequent comorbidities, and decades of generalized diagnostic frameworks contribute to high error rates and growing patient distr...
Default Mode Network Dysfunction in Treatment-Resistant Depression
Off-Label
40 minutes
4 months ago
Default Mode Network Dysfunction in Treatment-Resistant Depression
Description: For many facing depression, therapy and medication offer a way forward. But what happens when nothing seems to work? In this episode of Off Label: Data, Diagnostics, and the Future of Mental Health, Dr. Steve Rondeau explores how dysfunction in the brain’s Default Mode Network (DMN) may be a key driver behind Treatment-Resistant Depression (TRD). The DMN—often active during introspection and self-reflection—can become overactive, misaligned, or rigid in TRD, reinforcing ruminatio...
Off-Label
In this episode of Off Label, we unpack a paper by Dr. Steve Rondeau that tackles one of the biggest challenges in mental health care: diagnostic heterogeneity. When two patients present with the same symptoms but have entirely different underlying conditions, misdiagnosis becomes almost inevitable—and treatment suffers. The paper explains how overlapping symptoms, frequent comorbidities, and decades of generalized diagnostic frameworks contribute to high error rates and growing patient distr...
