“Is it time to do something big and different? That’s always a good question to ask,” said W. Kimryn Rathmell, MD, PhD, MMHC, the immediate former director of the National Cancer Institute (NCI) and the current CEO of The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute. At the 2025 American Society of Clinical Oncology Annual Meeting, Dr. Rathmell spoke with Robert A. Figlin, MD, the interim director of Cedars-Sinai Cancer in Los Angeles, and Steven Spielberg Family Chair in Hematology-Oncology, about how the NCI can adapt to the current environment. She also shared her thoughts on educating the next generation of cancer physicians. “How can we help enable them to look at every patient creatively and to think about how we incorporate all this immense amount of knowledge that we’re trying to impart with them?” she asked.