Dr Marshall highlights practice-changing research at ASCO GI (#GI25) and discusses the turmoil caused by the new presidential administration’s abrupt policy changes, which have disrupted federal health agencies, including the NIH and NCI. He shares his views on the impacts of grant freezes, research funding uncertainty, and restrictions on federal scientists, warning that these decisions jeopardize cancer research progress and patient care. Dr Marshall reflects on the emotional toll of ongoing uncertainty in healthcare, particularly the impact on both providers and patients. While doctors must stay strong for their patients, they too are grappling with anxiety about the future of research, funding, and patient care. He emphasizes the need for support among colleagues, urging teams to check in with each other so they can continue providing the best care possible.