Womb Echoes: Why Second Pregnancies Flourish and How Ageing Microbiomes Threaten Newborn Brains

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Pathocast in Review

Zd_creation

6 episodes

1 month ago

The Pathocast in Review adopts a journal club format to critically dissect the latest research in immunology, virology, and infectious disease. Join our panellist as they deep-dive into recently published studies in a roundtable discussion. Leaving no stone unturned—we cover groundbreaking work across basic science, translational research, and clinical studies that are pushing the boundaries of the field. follow us on: Instagram - instagram.com/pathocast_review Tiktok - www.tiktok.com/@pathocast_rev

Life Sciences

Science

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Life Sciences

Science

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Womb Echoes: Why Second Pregnancies Flourish and How Ageing Microbiomes Threaten Newborn Brains

Pathocast in Review

49 minutes 25 seconds

1 month ago

Womb Echoes: Why Second Pregnancies Flourish and How Ageing Microbiomes Threaten Newborn Brains

Welcome to Pathocast In Review – S1. Ep6 – The sixth instalment explore how maternal biology shapes the health and development of the next generation. We unpack the maternal immune mechanisms that support a successful pregnancy, focusing on the pivotal role of regulatory T cells (Tregs) in preventing miscarriage and ensuring tolerance in subsequent pregnancies. We then shift to the maternal microbiome, examining emerging evidence on how a mother’s microbial community can influence the neurological development of her newborn. Intriguingly, we discuss research showing that microbiomes from older mothers may impart subtle developmental impairments.

Papers in Review:

1. Pregnancy-acquired memory CD4+ regulatory T cells improvepregnancy outcome in mice (DOI: 10.1038/s41467-025-61572-w).

2. Maternal dysbiosis produces long-lasting behaviouralchanges in offspring (DOI: 10.1038/s41380-024-02794-0)

Moderator: NelisaMakaleni (@nelly_saciar)

Panelists: Blessing Moses (@emeraldeey) and ValenciaChauke

Production: Zd Creations

Creator: Immun-Vir JC

Music: iLethu (@Mphephethwa_sa)