🎙️ Pathognomia Podcast – Sepsis & Septic Shock

Sepsis is not just an ICU diagnosis — it’s one of the deadliest syndromes in medicine. In this episode, we take you to the emergency room: a patient with fever, hypotension, tachypnea, and altered mentation. From there, we journey into the science, signs, and management of sepsis, weaving together Harrison’s Principles of Internal Medicine, 22nd Edition with the latest Surviving Sepsis Campaign Guidelines (2021, reaffirmed 2024).

What you’ll hear:

The evolution from SIRS to Sepsis-3

How dysregulated immunity, endothelial injury, and metabolic collapse drive shock

Clinical features across organ systems — from encephalopathy to purpura fulminans

Modern diagnosis with SOFA, qSOFA, NEWS2, lactate, and biomarkers

Management pearls: Hour-1 bundle, fluids, vasopressors, antimicrobials, source control, adjunctive therapies

Landmark trials that shaped today’s practice

Future directions in sepsis care: phenotyping, immunotherapy, and AI

This isn’t a quick summary. It’s a deep dive — vivid, clinical, and evidence-based — crafted for doctors, residents, and medical students who want to integrate science into bedside reasoning.

Disclaimer:

This podcast is AI-generated audio content, created from authentic, evidence-based medical sources including Harrison 22nd Edition and the Surviving Sepsis Campaign Guidelines. It is for educational purposes only and not a substitute for professional medical advice.