Exercise isn’t just “nice to have” during cancer, it can function like treatment for the side effects: fatigue, muscle loss (sarcopenia), joint pain, neuropathy, weakness, and even lymphedema risk reduction.
In this episode of Patient from Hell, host + cancer survivor Samira Daswani sits down with Sami (exercise + cancer specialist focused on implementation) to break down what the research is finally confirming and what patients can do today, even with low energy, limited time, or zero equipment.We also unpack the headline-grabbing findings from the CHALLENGE Trial in colorectal cancer: a structured, coached exercise program was associated with a 28% lower risk of recurrence or new primary cancer and raises the bigger question: why isn’t exercise prescribed like medicine?
Key takeaways you’ll learn:
- Why strength training is the #1 lever for cancer-related fatigue + muscle loss
- How to reduce joint pain (including hormone-therapy related joint pain)Simple “wake the nerves up” tactics for neuropathy- Lymphedema: prevention vs management + why early assessment matters
- Chemo brain: why “automation” (classes + follow-alongs) can be the hack
- The starter protocol: 10–15 minutes, every other day
Chapter Codes
00:00 Exercise as “treatment” for cancer side effects (fatigue, sarcopenia, function)
00:30 Meet Sami: implementation theory (how she got into exercise + cancer)
02:37 “How I f***ed up into this” — origin story + early patient experiences
05:20 The headline research: what the CHALLENGE Trial showed
07:19 The big number: 28% lower recurrence/new primary (structured group)
08:40 Trial design: education vs coached/supervised exercise
11:03 Symptom playbook begins: what exercise helps most
11:35 Fatigue: why strength training rebuilds your “engine”
14:09 What counts as strength training (real-world examples)
15:46 Joint pain: lubrication, range of motion, yoga/Tai Chi basics
17:22 Hormone therapy joint pain: why feet + shoulders show up big
20:06 Plantar fasciitis: barefoot time + ball rolling + lifestyle traps
21:47 Neuropathy: “wake the nerves up” + balance + sensation tools
24:29 Lymphedema: prevention vs management + catch it early
28:04 Weakness: mitochondria, estradiol, and fast-twitch strength loss
30:34 Chemo brain: automate workouts so you don’t have to think
33:59 Safety fear: “If chemo didn’t kill you, a squat won’t” (starting smart)
38:33 Where to start: 10–15 minutes every other day
40:17 Two starter moves: sit-to-stands + countertop pushups
41:14 Just diagnosed? Keep routine—lower intensity + prioritize strength
42:25 Wrap + the bigger message: independence, quality of life, green light
About Patient From Hell
Patient From Hell is hosted by cancer survivor and founder Samira Daswani, who asks the questions most patients are too overwhelmed—or too afraid—to ask.
The show brings together doctors, researchers, advocates, and survivors to reveal evidence-based answers for patients navigating the chaos of cancer.
Subscribe for episodes that blend science, compassion, and clarity—without the medical jargon.
Connect & Follow Samira Daswani
LinkedIn: https://www.linkedin.com/in/samiradaswani/
Manta Cares: https://www.mantacares.com
Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard, or delay in obtaining, medical advice for any medical condition they may have, and should seek the assistance of their health care professionals for any such conditions.