Link for free CME Credit:  https://cmetracker.net/UTHSCSA/Publisher?page=pubOpen#/getCertificate/10099816 In this episode of Pediatrics Now, host and executive producer Holly Wayment welcomes back Dr. Ted Wu to explore the critical topic of sepsis in children. Dr. Wu, with 19 years of experience in pediatric critical care, discusses the intricacies of diagnosing and managing sepsis in neonates and infants, emphasizing the importance of early recognition and tailored treatment strategies. The episode delves into the latest research coming out of Cincinnati Children's Hospital, revealing groundbreaking techniques such as JEDI, which helps categorize sepsis patients based on genetic markers for more individualized care. Holly and Dr. Wu also touch upon real-life implications in pediatric practice, sharing essential warning signs of sepsis, particularly in viral seasons, and how general pediatricians can make critical interventions in the first hour of diagnosis. Listeners will gain valuable insights into the evolving landscape of sepsis treatment, including the role of antibiotics, fluid management, and the complex decisions pediatric practitioners face in urgent care settings. Tune in for a comprehensive discussion that balances medical knowledge with practical, on-the-ground advice for those encountering this life-threatening condition.