Link for free credit: https://cmetracker.net/UTHSCSA/Publisher?page=pubOpen#/getCertificate/10100930 In this episode, Rachel Vandermeer, MD, reviews pain assessment and treatment for children with medical fragility, focusing on altered pain pathways, common pain sources, and the need for multimodal, individualized plans. Practical recommendations include careful opioid use, gabapentinoids, clonidine for dysautonomia, prevention strategies around procedures, bowel regimens, and close outpatient follow-up to manage chronic neuro-agitation safely.