Holly Wayment interviews Dr. Alice Gong about updated newborn screening guidelines, expanded blood tests (now 59–60), additions like lysosomal storage disorders and SMA, point-of-care screens (hearing and critical congenital heart disease), and newborn blood spot retention and consent policies. The episode covers testing timelines, follow-up coordination between hospitals and pediatricians, counseling families about results, special considerations for premature or critically ill infants, and emerging genomic approaches.